The Eeffect of Cronobacter sakazakii on the Brains of Newborn Mice

Fifteenth of Cronobacter sakazakii were obtained from previous studies isolates (infant formula, spinal fluid and bloods). The newborn mice number was 15 obtaining healthy the Iraqi Center for Cancer Medical Genetics whose ages ranged between 10-17 days their weights 8.5 ± 1.25 gm, divided into 3 groups. samples cut placed in formalin, then stabilizer concentrations alcohol (70%, 80%, 90%,100%) to complete dehydration after they leached with xylene, embedded paraffin wax (58°C) sectioning thickness (5) micrometer stained Haematoxylin Eosin stain. results an increase weight brain organ compared control treatment this significant at probability level p≤0.05 showed inflammatory response large polymorphnuclear cells mononuclear as well congested blood vessels size endothelial cells. presence bleeding congestion shrinking nerve area cerebral cortex, gliosis (neuroma), more prominent molecular layer fed a concentration 105 occurrence oedema ,the haemorrhage both dosed necrosis choroid plexus concentration103